GLYOXYLIC ACID MONOHYDRATE

Glyoxylic acid monohydrate is a reagent for sulfinylmaleate synthesis.
Glyoxylic acid monohydrate is one of the chemicals used in the Hopkins Cole reaction.
Glyoxylic acid monohydrate is involved to check the presence of tryptophan in proteins.
Glyoxylic acid monohydrate is condensed with urea and 1,2-diaminobenzene to form heterocycles.
Glyoxylic acid monohydrate also undergoes Friedel-Crafts and cyclocondensation reactions to form bis(pentamethylphenyl) acetic acid and a beta-carboline respectively.
Glyoxylic acid monohydrate is employed in the synthesis of a sulfinylmaleate, which serves as an efficient dienophile for enantioselective Diels-Alder cycloadditions.

CAS: 563-96-2
IUPAC Name: oxaldehydic acid;hydrate
Molecular Formula: C2H4O4
Molecular Weight: 92.05 g/mol

Glyoxylic acid monohydrate, 2-oxoacetic acid hydrate, Glyoxylic Acid Hydrate, 1152495-30-1, oxaldehydic acid;hydrate, 6000-59-5, Oxoacetic Acid Monohydrate, oxaldehydic acid hydrate, glyoxalate, MFCD00149497, 2-OxoaceticAcid, glyoxalic acid hydrate, Glyoxalic acid monohydrate, glyoxalate, glyoxylate hydrate, dihydroxyketene-water, oxoacetate monohydrate, 2-oxoaceticacidhydrate, glyoxylic acid-hydrate, oxoacetic acid hydrate, glyoxylic acid-monohydrate, monohydrate glyoxylic acid, Glyoxilic acid monohydrate, OHCCO2H.H2O, bmse000471, glyoxilic acid mono-hydrate, 2-oxoacetic acid monohydrate, Oxoacetic acid--water (1/1), DTXSID30575892, Glyoxylic acid monohydrate, 98%, BCP15407, s3092, AKOS000121922, SB85390, DB-029874, DB-347291, F14188, A820060, Glyoxylic acid monohydrate, purum, >=97.0% (T), J-510223

Glyoxylic acid monohydrate is a versatile chemical used in various industries such as pharmaceuticals, agrochemicals, and cosmetics.
Glyoxylic acid monohydrate is commonly used as an intermediate in the production of chemicals like vanillin, amino acids, and herbicides.

Glyoxylic acid monohydrate is a reagent for sulfinylmaleate synthesis.

Glyoxylic Acid, Monohydrate, also known as oxoacetic acid or formylformic acid, is an organic compound and one of the C2 carboxylic acids.
Glyoxylic acid monohydrate can be used to check for the presence of tryptophan in proteins.

Glyoxylic acid monohydrate is extensively researched in the fields of organic synthesis and biochemistry, particularly for its role as a building block in the synthesis of various organic compounds.
Glyoxylic acid monohydrate's reactivity is studied for the production of bioactive compounds, flavorings, and aroma compounds, where it acts as a key intermediate.
Research on Glyoxylic acid monohydrate includes exploring its effectiveness in the formation of heterocyclic compounds and its use in the synthesis of vanillin, a widely used flavoring agent.
The stability and handling of Glyoxylic acid monohydrate under various conditions are also significant areas of study, aiming to optimize its use in industrial and laboratory settings.
Moreover, studies focus on the environmental impact of Glyoxylic acid monohydrate, particularly its biodegradability and potential effects on aquatic systems.

Glyoxylic acid monohydrate Powder is one of the numerous advanced ceramic materials.

Glyoxylic acid monohydrate is a colorless solid that exists in nature and is synthesizable.
Glyoxylic acid monohydrate is used in the industry for the production of agrochemicals, flavors, cosmetic ingredients, pharmaceutical intermediates, and polymers.
For example, Glyoxylic acid monohydrate is used in the synthesis of allantoin, which is widely used in dermatological preparations.

Glyoxylic acid monohydrate occurs in unripe fruit and in young green leaves; has also been found in very young sugar beets.

This white to yellow colored crystalline powder or chunks is freely soluble in water and can be an irritant to the eyes or skin.
Sometimes referred to as oxoacetic acid monohydrate, Glyoxylic acid monohydrate can be found in unripened fruit such as sugar beets and should be stored below 30 degrees Celcius.

Physiochemical properties: White powder, can be dissolved with water, slightly soluble in ethanol, aether, insoluble in esters, aromatic solvents.

Product advantage: White powder, including lower content of glyoxal, nitric acid, heavy metal, etc.than the solution product.
Compared with water solution, the yield increased, the side reaction decreased, it will improve the quality of the downstream products.

Glyoxylic Acid Monohydrate is a high purity, eco-friendly neutralizing agent.
Glyoxylic acid monohydrate is used to produce allantoin.
Glyoxylic Acid Monohydrate is suitable for lotions & creams, shampoos, conditioners and hair straightening products.

Empirical formula: C2H4O4
Molecular weight: 92.05080
CAS number: 563-96-2
EINECS number: None
Formic acid: 0.5%max
Maleic acid: 0.15%max
Oxalic acid: 1.35%max
Glyoxal: 0.0%
Density（20℃）: 1.33g/mL
CTFA/INCI name: Glyoxylic Acid Monohydrate
Appearance: White crystalline powder
Solubility: Very solute in water and alcohol, insoluble in organic solvents
Storage: Keep the containers well closed.
Storage temperatures lower than 40℃.

Use: Glyoxylic acid monohydrate is used as material for methyl vanillin, ethyl vanillin in flavor industry;
Glyoxylic acid monohydrate is used as intermediate for atenolol,D-hydroxybenzeneglycin, broadspectrum antibiotic, amoxicillin(orally taken),acetophenone,amino acid etc..
Glyoxylic acid monohydrate is used as intermediate of varnish material, dyes, plastic, agrochemical, allantoin and daily-use chemical etc..

Main Applications

Aromas:
Raw material of vanillin, Ethyl-vanillin, Heliotropin, Anisic Aldehyde etc.

Pharmaceutical intermediates
Glyoxylic acid monohydrate is used as pharm intermediates for D(-) Alpha Phenylglycine, Mandelic acid, Hydroxyphenylacetic acid, p-Hydroxyphenylglycine, p-Hydroxyphenylhydantoin , Diphenylacetic acid and so on.

Cosmetics
Glyoxylic acid monohydrate is used to produce Allantoin and Allantoin is suitable for any personal care application.
Glyoxylic acid monohydrate helps the dead skin cells fall off, helps the skin keep in more water, and leaves the skin feeling smoother and softer;
Glyoxylic acid monohydrate also finds applications in personal care as neutralizing agent and widely used in hair straightening products.

Agrochemical
Glyoxylic acid monohydrate is used as intermediates of herbicides and pesticides;
Also raw material for EDDHA-FE organic fertilizer.

Water Treatment Agent
Glyoxylic acid monohydrate can be used to manufacture water treatment agent 2-Hydroxyphosphonocarboxylic Acid (HPAA).

Other Applications
Glyoxylic acid monohydrate is used as raw material of vanish and dyes; Used to make water-soluble polymers and copolymers which are useful in coatings, adhesives;
Glyoxylic acid monohydrate is used as a chemical cross-linking agent etc.

Employed in the synthesis of a sulfinylmaleate, which serves as an efficient dienophile for enantioselective Diels-Alder cycloadditions.
Undergoes Friedel-Crafts and cyclocondensation reactions to form bis(pentamethylphenyl)acetic acid and a β-carboline, respectively.

By using glyoxylic acid monohydrate as a promoter, a wide range of substances containing a C–SO2 bond could be obtained from N-substituted maleimides or quinones and sodium sulfinates.
The protocol features mild reaction conditions, short reaction time, and good atomic economics, which provides an alternative protocol for the α-sulfonylation of α,β-unsaturated ketones.

Glyoxylic acid monohydrate Usage:

• For determination of protein in urine
• For the synthesis of a highly efficient dienophile thionyl maleic acid
• Glyoxylic acid monohydrate is used in Cosmetics, hair straightening, flavors and fragrances, agricultural fertilizers, and medicine.

Solubility
Soluble in water, dimethyl sulfoxide and alcohol.
Insoluble in diethyl ether and hydrocarbons.

Glyoxylic acid monohydrate is a reagent for sulfinylmaleate synthesis.

Notes
Hygroscopic.
Keep the container tightly closed in a dry and well-ventilated place.
Incompatible with bases, oxidizing agents and reducing agents.